期刊
CANCER LETTERS
卷 331, 期 2, 页码 200-210出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.12.027
关键词
Actin remodeling; Cell matrix; Cell adhesion; Hypoxia; Radiation; Stress fibers
类别
资金
- IZKF (Interdisziplinares Zentrum fur Klinische Forschung), University of Wurzburg, Germany [B-159]
This study explores the impact of Hsp90 inhibitors NVP-AUY922 and NVP-BEP800 in combination with ionizing radiation (IR) on the migration and invasion of lung carcinoma A549 and glioblastoma SNB19 cells, under normoxia or hypoxia. Independent of oxygen concentration, both drugs decreased the migration and invasion rates of non-irradiated tumor cells. Combined drug-IR treatment under hypoxia inhibited cell invasion to a greater extent than did each treatment alone. Decreased migration of cells correlated with altered expression of several matrix-associated proteins (FAK/p-FAK, Erla, RhoA) and impaired F-actin modulation. The anti-metastatic efficacy of the Hsp90 inhibitors could be useful in combinational therapies of cancer. (C) 2013 Elsevier Ireland Ltd. All rights reserved.
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