4.7 Article

piR-823, a novel non-coding small RNA, demonstrates in vitro and in vivo tumor suppressive activity in human gastric cancer cells

期刊

CANCER LETTERS
卷 315, 期 1, 页码 12-17

出版社

ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.004

关键词

PiRNA; Non-coding RNA; Carcinogenesis; Gastric cancer

类别

资金

  1. Natural Science Foundation of Ningbo [2010A610044]
  2. Zhejiang Provincial Research Project [2010C33112]
  3. Natural Sciences Foundation of Zhejiang [Y207244]
  4. National Natural Science Foundation of China [30872420, 81171660]
  5. Zhejiang Provincial Education Department for Innovation Team [T200907]
  6. Scientific Research Foundation of the Graduate School of Ningbo University [G10JA026]
  7. Ningbo University [201014]

向作者/读者索取更多资源

Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.

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