期刊
CANCER LETTERS
卷 315, 期 1, 页码 12-17出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.004
关键词
PiRNA; Non-coding RNA; Carcinogenesis; Gastric cancer
类别
资金
- Natural Science Foundation of Ningbo [2010A610044]
- Zhejiang Provincial Research Project [2010C33112]
- Natural Sciences Foundation of Zhejiang [Y207244]
- National Natural Science Foundation of China [30872420, 81171660]
- Zhejiang Provincial Education Department for Innovation Team [T200907]
- Scientific Research Foundation of the Graduate School of Ningbo University [G10JA026]
- Ningbo University [201014]
Piwi-interacting RNAs (piRNAs), new non-coding small RNAs, are association with chromatin organization, messenger RNA stability and genome structure. However, the roles of piRNA in carcinogenesis are not clearly defined. By using real-time reverse transcription-polymerase chain reaction technology, we found that the expression level of piR-823 in gastric cancer tissues was significant lower than that in non-cancerous tissues. After increase the level of piR-823 in gastric cancer cells, cell growth was inhibited. The results of xenograft nude mice model confirmed its tumor suppressive properties. All of the evidences indicated that piR-823 play a crucial role in the occult of gastric cancer. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据