期刊
CANCER LETTERS
卷 324, 期 1, 页码 48-57出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.04.019
关键词
HER2; SV40 T/t-common; Chemosensitization; Antitumor; Apoptosis
类别
资金
- National Science Council, Taiwan [NSC93-3112-B-002-014, NSC95-2320-B-002-093, NSC96-2320-B-002-035-MY3, NSC99-2320-B-002-009-MY3]
HER2-overexpressing cancer cells are resistant to cisplatin (CDDP) and doxorubicin (DXR). Here we report that SV40 T/t-common polypeptide could specifically sensitize HER2-overexpressing cancer cells to CDDP and DXR and specifically enhance CDDP- or DXR-induced apoptosis in these cells. This activity of Tit-common may be attributed to its ability to inhibit Bcl-2 and Bcl-XL and to suppress ERK activity in CDDP- or DXR-treated HER2-overexpressing cancer cells. T/t-common could enhance the antitumor activity of DXR on HER2-overexpressing ovarian tumor in NOD/SCID mice, suggesting that combination therapy using T/t-common and chemotherapeutic agents may provide a new approach for treating HER2-overexpressing cancers. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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