期刊
HIPPOCAMPUS
卷 17, 期 10, 页码 1003-1011出版社
WILEY
DOI: 10.1002/hipo.20332
关键词
cA3 neurons; NMDA receptors; long-axis
资金
- NATIONAL INSTITUTE OF MENTAL HEALTH [P50MH058880] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG025161, P50AG008702] Funding Source: NIH RePORTER
- NIA NIH HHS [AG025161, P50 AG008702] Funding Source: Medline
- NIMH NIH HHS [MH058880] Funding Source: Medline
The anatomical distribution of sensory-evoked activity recorded from the hippocampal long-axis can shift depending on prior experience. In accordance with Marr's computational model of hippocampal function, CA3 NMDA receptors have been hypothesized to mediate this experience-dependent shift in hippocampal activity. Here we tested this hypothesis by investigating genetically-modified mice in which CA3 NMDA receptors are selectively knocked-out (CA3-NR1 KO). First, we were required to develop an fMRI protocol that can record sensoryevoked activity from the mouse hippocampal long-axis. This goal was achieved in part by using a dedicated mouse scanner to image odorevoked activity, and by using non-EPI (echo planer imaging) pulse sequences. As in humans, odors were found to evoke a ventral-predominant activation pattern in the mouse hippocampus. More importantly, odor-evoked activity shifted in an experience-dependent manner. Finally, we found that the experience-dependent shift in hippocampal long-axis activity is blocked in CA3-NR1 knock-out mice. These findings establish a cellular mechanism for the plasticity imaged in the hippocampal long-axis, suggesting how experience-dependent modifications of hippocampal activity can contribute to its mnemonic function. (c) 2007 Wiley-Liss, Inc.
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