期刊
CANCER LETTERS
卷 319, 期 1, 页码 8-22出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.026
关键词
Vitamin D; Hematological malignancies; Intracellular kinases; Multiple myeloma; Clinical trials
类别
资金
- TTUHSC
The role of vitamin D in the inhibition of malignant cell proliferation in hematological malignancies is indicative of its future use in cancer therapy. An understanding of the biochemical mechanism by which vitamin D and its derivatives exert their effects will prove to be useful in the development of clinically applicable therapies involving vitamin D. While the use of vitamin D in clinical trials against acute myeloid leukemia and myelodysplastic syndrome has been met with few successes thus far, in vitro and in vivo studies as well as epidemiological correlations between vitamin D deficiency and cancer have implicated the great potential of the use of vitamin D derivatives in effective therapies against neoplastic diseases. For these reasons, a focus on current understanding of role of vitamin D and derivatives in hematologic malignancies is relevant and the goal for this review. Published by Elsevier Ireland Ltd.
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