期刊
CANCER LETTERS
卷 315, 期 2, 页码 129-137出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.012
关键词
Hepatocellular carcinoma; Cancer stem cell; Radioresistance; CD133; Microarray
类别
资金
- Ministry of Science and Technology, the Republic of Korea [2010-0017595]
- National Research Foundation of Korea (NRF)
- Korea government (MEST) [2011-0027071]
- National Research Foundation of Korea [2010-0025007] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
CD133 is a cancer stem-cell (CSC) marker associated with radioresistance and chemoresistance in various cancers. In the present study, CD133-expressing liver cancer cells following radiation exposure showed higher activation of MAPK/PI3K signaling pathway and reduction in reactive oxygen species levels compared to CD133(-) cells. The in vivo study with a xenograft model showed increased tumor formation in irradiated CD133(+) cell-injected nude mice compared to the CD133(-) group, suggesting that CD133 contributes to radioresistance in HCC. Therefore, CD133-expressing liver cancer cells have anti-apoptotic and radioresistance properties that may be useful to improve anti-cancer treatments, including chemotherapy/radiotherapy of HCC. Crown Copyright (C) 2011 Published by Elsevier Ireland Ltd. All rights reserved.
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