期刊
CANCER LETTERS
卷 316, 期 1, 页码 85-90出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.10.028
关键词
Tumorigenic transformation; Colorectal cancer; Cell-free nucleic acids; Genometastasis; NIH-3T3 fibroblasts
类别
资金
- Instituto de Salud Carlos III, Ministry of Science, Spain [PS09/01815, PS09/00874]
The ability of cells to undergo cellular transitions, in particular, to switch between epithelial and mesenchymal states, might be highly advantageous during the progression of carcinoma. Using histological and immunohistochemical techniques, we here show that the injection into mice of spontaneously transformed NIH-3T3 cells generated fusocellular sarcomas, whereas NIH-3T3 cells that had been transformed by culturing with plasma from colorectal cancer patients gave rise to tumors that phenotypically resembled the carcinomas of the original cancer patients. Thus, plasma from cancer patients is able to transform NIH-3T3 fibroblasts into malignant epithelial-like cells, suggesting that such cells might undergo mesenchymal to epithelial transition during plasma-induced transformation. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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