期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 24, 期 6, 页码 441-447出版社
KARGER
DOI: 10.1159/000110577
关键词
Alzheimer's disease; frontotemporal dementia; Philadelphia brief assessment of cognition; neuropsychological assessment
资金
- NIA NIH HHS [AG17586, AG15116, AG10124, R01 AG015116, P01 AG017586] Funding Source: Medline
- NINDS NIH HHS [NS44266, R01 NS044266] Funding Source: Medline
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS044266] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [R01AG015116, P30AG010124, P01AG017586] Funding Source: NIH RePORTER
Background: A neuropsychological screening instrument sensitive to neuropsychological deficits associated with Alzheimer's disease ( AD) and patients with frontotemporal dementia (FTD) would be valuable for diagnostic evaluation. Methods: The Philadelphia Brief Assessment of Cognition (PBAC) assesses working memory/executive control, language, visuospatial operations, verbal/visual episodic memory, and behavior/social comportment and can be administered and scored in 15-20 min. Participants included 149 patients with AD and four groups of FTD patients - i.e., patients with a decline in social comportment, personality, and executive functioning (SOC/EXEC), semantic dementia (SemD), progressive nonfluent aphasia (PNFA), and corticobasal syndrome (CBS). Results: The total PBAC score correlated with the Mini-Mental State Examination. Between-group analysis of PBAC subscales and the results of logistic regression analyses produced substantial between-group differences, emphasizing the sensitivity of the test to differentiate dementia subtypes. AD patients were impaired on tests of episodic memory, SOC/EXEC patients were impaired on a measure of social comportment/behavioral disturbance, PNFA patients obtained low scores on tests of working memory/executive control, SemD patients obtained lower scores on language-mediated measures, and CBS patients were impaired on visuospatial/visual memory tests. Conclusion: These data support the usefulness of the PBAC as a relatively brief screening test of overall dementia severity across a wide range of dementia patients. Copyright (c) 2007 S. Karger AG, Basel.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据