期刊
CANCER LETTERS
卷 325, 期 1, 页码 89-98出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.06.005
关键词
Latent transforming growth factor beta binding protein 2 (LTBP-2); Nasopharyngeal carcinoma (NPC); Anti-angiogenesis; Tumor suppression; Tumor cell dormancy; Metastatic growth
类别
资金
- University Grants Council [AoE/M-06/08]
- Finnish Cancer Foundation
- Swedish Cancer Society
- Swedish Research Council
- Swedish Institute
- Karolinska Institute
This study identified LTBP-2 as a pleiotropic tumor suppressor in nasopharyngeal carcinoma, which safeguards against critical malignant behaviors of tumor cells. LTBP-2 expression was significantly decreased or lost in up to 100% of NPC cell lines (7/7) and 80% of biopsies (24/30). Promoter hypermethylation was found to be involved in LTBP-2 silencing. Using a tetracycline-regulated inducible expression system, we unveiled functional roles of LTBP-2 in suppressing colony formation, anchorage-independent growth, cell migration, angiogenesis, VEGF secretion, and tumorigenicity. Three-dimensional culture studies suggested the involvement of LTBP-2 in maintenance of tumor cell dormancy in a growth factor favorable microenvironment. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
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