期刊
CANCER LETTERS
卷 323, 期 2, 页码 147-154出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2012.03.042
关键词
RRAD; Nasopharyngeal carcinoma; Methylation
类别
资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [19406021, 22406016]
- National Basic Research Program of China [2011CB504301]
- National Natural Foundation of China [30860311]
- Grants-in-Aid for Scientific Research [24390172, 23390162, 23659328, 22406016, 23659327, 24390153, 19406021, 22406006] Funding Source: KAKEN
Nasopharyngeal carcinoma (NPC) is endemic in southern China. In a genome-wide screen for genes inactivated by promoter hypermethylation, we identified Ras-related associated with diabetes (RRAD). Expression of RRAD was down-regulated in 83.3% (30/36) of the biopsies from NPC patients. RRAD was aberrantly methylated in 74.3% (26/35) of primary tumors, but not in normal nasopharyngeal epithelium. Ectopic RRAD expression in NPC cell lines inhibited the cell growth, colony formation, and cell migration. These results indicate that RRAD might act as a functional tumor suppressor and its epigenetic inactivation may play an important role in NPC development. (c) 2012 Elsevier Ireland Ltd. All rights reserved.
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