期刊
DEMENTIA AND GERIATRIC COGNITIVE DISORDERS
卷 23, 期 6, 页码 432-438出版社
KARGER
DOI: 10.1159/000101990
关键词
Alzheimer's disease; mild cognitive impairment; sigma receptor type 1 gene
The sigma-1 receptor (SIGMAR1) is a subtype of a nonopioid sigma receptor family and is implicated in numerous functions connected with Alzheimer's disease ( AD). Two common genetic variants were identified in SIGMAR1: GC - 241 - 240TT and Q2P (A61C). It was suggested that the TT-C haplotype is a protective factor for AD. We decided to investigate a putative link between the variants of SIGMAR1 and AD in a group of Polish patients with late-onset AD, in patients with mild cognitive impairment, and in a control group. We observed no significant differences for the SIGMAR1 allele, genotype, haplotype, and diplotype distributions between the studied groups. Multivariate logistic regression analysis showed no interaction between the APOE4 and SIGMAR1 polymorphisms. Further studies using data from different populations are required to elucidate the effect of SIGMAR1 polymorphisms on AD. Copyright (c) 2007 S. Karger AG, Basel.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据