期刊
CANCER LETTERS
卷 301, 期 2, 页码 142-150出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.11.005
关键词
GITRL; BMDC; Recombinant adenovirus
类别
资金
- National Natural Science Foundation of China [81072453, 30871193, 30972748, 30910103087]
- Natural Science Foundation of Jiangsu Province [BK2004405]
- Natural Science Foundation of Jiangsu Province Educational Commission [08KJB320002]
- Health Department Foundation of Jiangsu Province [H200952]
- Jiangsu University
Glucocorticoid-induced tumor necrosis factor receptor and its ligand (GITRL) are critic. involved in the regulation of immune response. In this study, we aimed to generate marrow-derived dendritic cells (BMDCs) transfected with recombinant adenovi expressing GITRL (pAd-GITRL-BMDCs) and explore their therapeutic efficacy in mut Lewis lung carcinoma. In vitro, pAd-GITRL-BMDCs greatly enhanced effector T cells prc eration but markedly abrogate the suppression of Treg cells. Moreover, vaccination it pAd-GITRL-BMDCs significantly retarded tumor growth, which was accompanied It. increased IFN-gamma-producing CD8+ T cells and markedly decreased Treg cells in vivo. Th findings suggest GITRL could enhance the immune stimulation of DC and might facilit the potential development of DCs-based anti-tumor therapies. (c) 2010 Elsevier Ireland Ltd. All rights reserved
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