期刊
CANCER LETTERS
卷 312, 期 1, 页码 33-42出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2011.07.025
关键词
Nuclear receptor; HCC; HBV; HDAC; Hepatocarcinogenesis
类别
资金
- Ministry of Education, Culture, Sports, Science, and Technology, Japan [21590829]
- Chiba University
- Grants-in-Aid for Scientific Research [21590829] Funding Source: KAKEN
Recent studies have implicated nuclear receptors (NRs) in the development of hepatocarcinogenesis. We assumed that hepatitis B virus (HBV) alters the expression of NRs and coregulators, and compared the gene expression profiling for 84 NRs and related genes between HpeG2.2.15, which secretes complete HBV virion, and HepG2 by real-time RT-PCR with SyBr green. Forty (47.6%) genes were upregulated 2-fold or greater, and only 5(5.9%) were down-regulated 2-fold or more, in HepG2.2.15 compared to HepG2. These results suggest that HBV affects NRs and their related signal transduction, and that they play important roles in viral replication and HBV-related hepatocarcinogenesis. (C) 2011 Elsevier Ireland Ltd. All rights reserved.
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