期刊
PHARMACEUTICAL BIOLOGY
卷 45, 期 5, 页码 355-359出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13880200701212973
关键词
acetic acid-induced writhing response; anti-inflammatory; carrageenan-induced rat paw edema assay; Euphorbiaceae; Phyllanthus reticulatus; radiant heat tail-flick method
The petroleum ether, ethyl acetate, and methanol extracts of Phyllanthus reticulatus Poir. (Euphorbiaceae) were chosen for pharmacological screening. In the acetic acid-induced writhing test, the ethyl acetate extract in doses of 150 and 300 mg/kg showed 51.23 and 65.12% inhibition of writhing, respectively. A significant elongation of tail-flick time was evident both in the ethyl acetate and the methanol extracts (42.38 and 60.49%) only at the 300 mg/kg dose level. In carrageenan-induced rat paw edema model, the methanol extract at the 300 mg/kg dose level showed 40.03% inhibition of edema at the end of 4 h. These results demonstrated that the extracts of P. reticulatus possess significant analgesic and anti-inflammatory properties.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据