期刊
CANCER LETTERS
卷 297, 期 1, 页码 101-108出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.05.001
关键词
DJ-1; Tumorigenesis; Autophagy; Beclin 1; JNK
类别
资金
- National Natural Sciences Foundation of China [30770664, 30970921]
- National High-tech Research and Development program of China [2006CB500703, 2006AA02A408]
- CAS [KSCX2-YW-R138]
Autophagy mediates cellular self-digestion to degrade cytoplasmic proteins and organelles and plays important roles in tumorigenesis. DJ-1 is an oncogene product in association with cancers and tumorigenesis. In this study, we show that knockdown of DJ-1 induces autophagy through activating INK pathway to promote Beclin 1 transcription, whereas overexpression of DJ-1 inhibits these processes. Moreover, inhibition of JNK pathway by SP600125 blocks autophagy activation and p62 degradation induced by knockdown of DJ-1. Our findings suggest that DJ-1 regulates autophagy in a JNK-dependent manner. Thus, the involvement of DJ-1 in autophagy regulation may be involved in tumorigenesis. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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