期刊
CANCER LETTERS
卷 293, 期 1, 页码 65-72出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.12.018
关键词
C6 glioma; Cancer stem cells; Curcumin; Side population
类别
资金
- Department of Defense
- Cancer Institute of New Jersey
- American Institute for Cancer Research
- National Institutes of Health
- Aresty Research Center for Undergraduates at Rutgers University
The phytochemical curcumin, from the Indian spice turmeric, has many biological properties, including anti-inflammatory and anti-carcinogenic activities. We have examined the effects of curcumin on the rat C6 glioma cell line. Treated and control cells were analyzed by Hoechst 33342 dye and flow cytometry. We observed a decrease in the side population (SP) of C6 cells after daily curcumin treatment of the C6 cells. Direct incubation of curcumin to C6 cells during the Hoechst assay also decreased SP. Since SP has been associated with stem cell populations, curcumin may be a dietary phytochemical with potential to target cancer stem cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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