期刊
AMERICAN JOURNAL OF PHARMACEUTICAL EDUCATION
卷 71, 期 6, 页码 -出版社
AMER ASSOC COLL PHARMACY
DOI: 10.5688/aj7106122
关键词
medicinal chemistry; acid-base chemistry; acid-base equilibria; Henderson-Hasselbalch equation
Despite repeated exposure to the principles underlying the behavior of organic acids and bases in aqueous solution, some pharmacy students remain confused about the topic of acid-base chemistry. Since a majority of organic drug molecules have acid-base character, the ability to predict their reactivity and the extent to which they will ionize in a given medium is paramount to students' understanding of essentially all aspects of drug action in vivo and in vitro. This manuscript presents a medicinal chemistry lesson in the fundamentals of acid-base chemistry that many pharmacy students have found enlightening and clarifying
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