期刊
CANCER LETTERS
卷 289, 期 2, 页码 140-150出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.07.004
关键词
KSHV; Oncogenesis; AIDS-related malignancies; Viral latency; Lytic replication
类别
资金
- NIAID [T32-AI007001]
- MSTP [T32-GM008719]
- NIH [CA096500, DE18281, HL083469]
Kaposi sarcoma-associated herpesvirus (KSHV) is a double-stranded DNA herpesvirus belonging to the gamma-herpesvirinae subfamily. KSHV has been associated with the development of three neoplastic diseases: Kaposi sarcoma (KS), primary effusion lymphoma (PEL), and multicentric Castleman disease (MCD). In this review, we discuss the three KSHV-associated malignancies, KSHV genome, latent and lytic aspects of the viral lifecycle, putative viral oncogenes, as well as therapeutic regimens used for the treatment of KS, PEL, and MCD. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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