期刊
CANCER LETTERS
卷 292, 期 2, 页码 141-148出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.11.012
关键词
Notch; miRNA; Cancer; Signaling; Therapy; Nutrition
类别
资金
- National Cancer Institute, NIH [5R01CA131151, 5R01CA083695, 1R01CA132794, 1R01CA101870]
- Department of Defense [W81XWH-08-1-0196]
- University of Texas MD Anderson Cancer Center [5P20-CA101936]
Notch signaling pathways are known to regulate many cellular processes. including cell proliferation, apoptosis, migration. invasion. and angiogenesis, and is one of the most important signaling pathway during normal development. Recently, emerging evidences suggest that microRNAs (miRNAs) can function as key regulators of various biological and pathologic processes during tumor development and progression Notch signaling has also been reported to be regulated through cross-talk with many pathways and factors where miRNAs appears to play a major role This article will provide a brief overview of the published evidences for the cross-talks between Notch and miRNAs Further, we summarize how targeting miRNAs by natural agents could become a novel and safer approach for the prevention of tumor progression and treatment. (C) 2009 Elsevier Ireland Ltd All rights reserved
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