期刊
CANCER LETTERS
卷 295, 期 1, 页码 59-68出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.02.014
关键词
EGFR; Mutants; Drug-resistance; Growth; Invasion; DIM
类别
资金
- NIH [RO1 CA106429]
- NATIONAL CANCER INSTITUTE [R01CA106429] Funding Source: NIH RePORTER
Epidermal Growth Factor Receptor (EGFR) mutants are associated with resistance to chemotherapy, radiation, and targeted therapies. Here we found that the phytochemical 3,3'-Diindolylmethane (DIM) can inhibit the growth and also the invasion of breast cancer, glioma, and non-small cell lung cancer cells regardless of which EGFR mutant is expressed and the drug-resistant phenotype. DIM reduced an array of growth factor signaling pathways and altered cell cycle regulators and apoptotic proteins favoring cell cycle arrest and apoptosis. Therefore, DIM may be used in treatment regimens to inhibit cancer cell growth and invasion, and potentially overcome EGFR mutant-associated drug resistance. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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