期刊
CANCER LETTERS
卷 293, 期 2, 页码 167-174出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.01.006
关键词
Esophageal cancer; Targeted therapy; Bcl-2 inhibitor; Autophagy
类别
资金
- National High Technology Research and Development Program of China [2008AA02Z420]
- National Natural Science Fund of China [90713036, 30801136]
- National Basic Research Program of China [2009CB825506]
Despite improvements in both surgical techniques and radio- and chemo-therapy regimens, the prognosis of esophageal cancer is poor. In pursuit of novel effective strategy, this study examined the effect of the BH3-mimetic GX15-070 on esophageal carcinoma cells. We discovered that GX15-070 inhibited the growth of esophageal cancer cells. There was synergism between GX15-070 and carboplatin or 5-fluorouracil. GX15-070 induced autophagy in esophagus cancer cell line EC9706 and osteosarcoma cancer cell line U2OS. 3-methyladenine and chloroquine, inhibitors of autophagy with distinct mechanisms, potentiated the cytotoxicity of GX15-070. In conclusion, GX15-070 inhibits growth of esophageal cancer cells. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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