期刊
JOURNAL OF ANESTHESIA
卷 21, 期 2, 页码 212-219出版社
SPRINGER TOKYO
DOI: 10.1007/s00540-006-0486-6
关键词
K(ATP) channel; mitochondria; myocardium; preconditioning; volatile anesthetics
资金
- NHLBI NIH HHS [HL 034708] Funding Source: Medline
- NIGMS NIH HHS [GM066730] Funding Source: Medline
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [R01HL034708] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [P01GM066730] Funding Source: NIH RePORTER
Pharmacological preconditioning with volatile anesthetics, or anesthetic-induced preconditioning (APC), is a phenomenon whereby a brief exposure to volatile anesthetic agents protects the heart from the potentially fatal consequences of a subsequent prolonged period of myocardial ischemia and reperfusion. Although not completely elucidated, the cellular and molecular mechanisms of APC appear to mimic those of ischemic preconditioning, the most powerful endogenous cardioprotective mechanism. This article reviews recently accumulated evidence underscoring the importance of mitochondria, reactive oxygen species, and K(ATP) channels in cardioprotective signaling by volatile anesthetics. Moreover, the article addresses current concepts and controversies regarding the specific roles of the mitochondrial and the sarcolemmal K(ATP) channels in APC.
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