期刊
NEOPLASIA
卷 9, 期 1, 页码 18-22出版社
ELSEVIER SCIENCE INC
DOI: 10.1593/neo.06661
关键词
paclitaxel; cisplatin; transitional cell carcinoma; salvage therapy; urothelium
类别
BACKGROUND: This study was performed to evaluate the safety and efficacy of paclitaxel with cisplatin as salvage therapy in patients previously treated with gemcitabine and cisplatin (G/C) for advanced transitional cell carcinoma (TCC) of the urothelial tract. METHODS: Twenty-eight patients with metastatic or locally advanced TCC who had received prior G/C chemotherapy were enrolled. All patients received paclitaxel (175 mg/m(2)) and cisplatin (60 mg/m(2)) every 3 weeks for eight cycles or until disease progression. RESULTS: The median age was 61 years (range, 43 83 years), and the median Eastern Cooperative Oncology Group performance status was 1 (range, 0-2). The overall response rate was 36% [95% confidence interval (95% CI) = 18 - 54], with three complete responses and seven partial responses. The median time to progression was 6.2 months (95% CI = 3.9 - 8.5), and the median overall survival was 10.3 months (95% CI = 6.1 - 14.1). The most common Grade 3/4 nonhematologic and hematologic toxicities were emesis (10 of 28 patients; 36%) and neutropenia (5 of 110 cycles; 5%). CONCLUSIONS: Salvage chemotherapy with paclitaxel and cisplatin displayed promising results with tolerable toxicity profiles in patients with metastatic or locally advanced TCC who had been pretreated with G/C.
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