期刊
CANCER LETTERS
卷 288, 期 2, 页码 177-182出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.06.037
关键词
Adiponectin; Colorectal cancer; Apc(Min/+) mice
类别
资金
- Grants-in-Aid for Scientific Research [21390015, 22659013] Funding Source: KAKEN
Recent reports have shown that adiponectin has a suppressive effect on various types of malignancy. In order to clarify the role of adiponectin in colorectal carcinogenesis, we examined the effect of exogenous administration of adiponectin on intestinal polyp formation in C57BL/6J-Apc(Min/+) mice, which possess a point mutation in the Apc gene. And we found that adiponectin treatment significantly decreased the number of adenomatous polyps, especially polyps larger than 2 mm in diameter, in the small intestine. Two major receptors for adiponectin, AdipoR1 and AdipoR2, were expressed in adenomatous polyps, and their expression levels were not altered by adiponectin injection. in conclusion, adiponectin suppresses the growth of intestinal adenomas in the Apc(Min/+) mice. Increasing the adiponectin level may be a new strategy for the prevention of colorectal cancer at an early step of carcinogenesis. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据