期刊
CANCER LETTERS
卷 296, 期 2, 页码 249-256出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2010.04.015
关键词
Angiogenesis; Gastric cancer; mTOR; Sunitinib; VEGF
类别
VEGF receptor blockage has been reported to increase serum VEGF. We hypothesized that mTOR inhibition by everolimus counteracts VEGF induction by sunitinib resulting in an improved anti-tumor activity of sunitinib. In vitro, sunitinib in combination with everolimus did not outperform the respective monotherapies. In vivo, monotherapies reduced tumor growth by 60%, whereas the combination of sunitinib and everolimus led to an almost complete tumor growth inhibition. This superior anti-tumor activity coincided with attenuation of VEGF peaks. In conclusion mTOR inhibition by everolimus counteracts VEGF induction by sunitinib and results in significant reduction of tumor burden and long-lasting tumor growth control. (C) 2010 Elsevier Ireland Ltd. All rights reserved.
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