期刊
CHIMIA
卷 61, 期 5, 页码 276-278出版社
SWISS CHEMICAL SOC
DOI: 10.2533/chimia.2007.276
关键词
Aldol reaction; asymmetric catalysis; combinatorial chemistry; pepticles
The article summarizes our research devoted to the development of peptidic catalysts for aldol reactions. Using the combinatorial method of 'catalyst-substrate coimmobilization' the peptides H-Pro-Pro-Asp-NH2 and H-Pro-D-Ala-D-Asp-NH2 were identified as highly active and selective catalysts for direct aldol reactions. The results demonstrate that the higher complexity of peptides in comparison to rigid small organocatalysts can be a good trade-off for higher activity.
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