期刊
CANCER LETTERS
卷 282, 期 2, 页码 125-136出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.12.011
关键词
Reactive oxygen species; Oxidative stress; Prostate cancer; Aging; Mitochondrial DNA mutation
类别
资金
- NIH/NCI [P20 CA103680]
- University of Colorado Cancer Center
- Department of Surgery-School of Medicine Academic Enrichment Funds
As prostate cancer and aberrant changes in reactive oxygen species (ROS) become more common with aging, ROS signaling may play an important role in the development and progression of this malignancy. Increased ROS, otherwise known as oxidative stress is a, result of either increased ROS generation or a loss of antioxidant defense mechanisms. Oxidative stress is associated with several pathological conditions including inflammation and infection. ROS are products of normal cellular metabolism and play vital roles in stimulation of signaling pathways in response to changing intra- and extracellular environmental conditions. Chronic increases in ROS over time are known to induce somatic mutations and neoplastic transformation. In this review we summarize the causes for increased ROS generation and its potential role in etiology and progression of prostate cancer. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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