期刊
CANCER LETTERS
卷 276, 期 2, 页码 171-179出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.11.025
关键词
Migration; Invasion; Sphingosine 1-phosphate; WiT49; Wilms tumor
类别
资金
- NIH [k08DK070468A]
- Seraph Foundation
- AHA Scientist Development Grant
Sphingosine-1-phosphate (S1P) is an important regulator of cellular functions via interaction with its receptors S1P(1-5). To date, nothing is known about the S1P receptor expression and the effects of S1P signaling in Wilms tumor. In this study, we found ubiquitous expression of S1P receptors in Wilms tumor specimens and cell lines. We demonstrated that S1P(1) acted as a promigratory modulator by employing S1P(1) antagonist VPC44116, S1P(1) siRNA and adenoviral transduction in Wilms tumor cells. Further, we clarified that S1P(1)-mediated migration occurred via Gi coupling and activation of PI3K and Rac1. In addition, S1P stimulated WiT49 cell invasion through S1P(1)/Gi signaling pathway. We consider that targeting S1P(1) may be a point of therapeutic intervention in Wilms tumor. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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