期刊
CANCER LETTERS
卷 282, 期 2, 页码 238-243出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.03.020
关键词
Resveratrol; Dihydroceramide; Autophagy; Desaturase; Cancer
类别
资金
- Doctorate School of Molecular Medicine
- Universita degli Studi di Milano
- Spanish National Research Council
- Generalitat de Catalunya [SGR200501063]
- Spanish Ministry of Science and Innovation [SAF2008-00706]
- Italian Program for University Research
Resveratrol has both apoptosis and autophagy-promoting activities in different cancer cells. Dihydroceramide is the immediate precursor of the apoptotic mediator ceramide in the de novo sphingolipid synthesis pathway. Here we demonstrate that resveratrol induces autophagy in HGC-27 cells, with no sign of cell death. Autophagy occurs after an increase in dihydroceramides by inhibition of dihydroceramide desaturase. The effects of resveratrol are mimicked by a dihydroceramide desaturase inhibitor. These results demonstrate that resveratrol-induced autophagy occurs with a rise in intracellular dihydroceramide levels as the result of inhibition of dihydroceramide desaturases activity and that dihydroceramide accumulation is responsible for autophagy promotion. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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