期刊
CANCER LETTERS
卷 283, 期 2, 页码 168-175出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.03.041
关键词
Microvesicles; Melanoma; Metastasis; Phosphatidylserine; TGF-beta(1)
类别
资金
- Instituto Nacional do Cancer (INCa)/FundaqAo Ary Frauzino para Pesquisa e Controle do CSncer (FAF)
Exposure of phosphatidylserine (PS) on cellular membranes and membrane-derived microvesicles stimulates a number of anti-inflammatory responses involved in malignant processes. Herein we show that B16F10 cells, a highly metastatic melanoma cell line, produce large quantities of PS-containing microvesicles in vitro. Tumor microvesicles increased TGF-beta(1) production by cultured macrophages and, in vivo, enhanced the metastatic potential of B16F10 cells in C57BL/6 mice, both effects being reversed by annexin V. Most strikingly, microvesicles induced melanoma metastasis in BALB/c mice, which are normally resistant to this tumor cell line. Altogether, this is the first demonstration that tumor-derived microvesicles favor the establishment of melanoma metastasis in a PS-dependent manner, possibly by down-regulating the host's inflammatory and/or anti-tumoral immune responses. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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