期刊
CANCER LETTERS
卷 281, 期 2, 页码 128-133出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.11.023
关键词
Apoptosis; Caspase-8; Cancer
类别
资金
- Deutsche Forschungsgemeinschaft
- Deutsche Krebshilfe
- Bundesministerium fur Forschung und Technologie
- Else-Kroner-Fresenius Stiftung
- European Community
- DAAD/INCA
- [IAP6/18]
Caspase-8 belongs to the caspase family of proteases and plays a key role in the regulation of programmed cell death (apoptosis) during normal development as well as in adult life. Since signaling via the death receptor (extrinsic) pathway critically depends on caspase-8, the disturbance of caspase-8 expression or function may contribute to human diseases. For example, caspase-8 is inactivated in a variety of human cancers, which may promote tumor progression as well as resistance to current treatment approaches. Therefore, caspase-8 presents a promising target to restore defective apoptosis programs in cancels in order to overcome resistance. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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