期刊
CANCER LETTERS
卷 285, 期 2, 页码 218-224出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.05.021
关键词
Anginex; Peptide; Angiogenesis; Anti-angiogenesis; Recombinant adenovirus
类别
资金
- Plan of Science and Technology Foundation of Shanxi Province [2004K11-G3]
- National Ministry of Education [Z2005-271001]
Anginex is a novel artificial peptide that can inhibit angiogenesis. AdNT4-anginex was constructed by inserting the artificial anginex gene into a recombinant adenoviral vector. We demonstrated that AdNT4-anginex inhibited migration of human endothelial cells, angiogenesis and tumor growth in in vitro and in vivo studies. Tumor growth of human H22 hepatoma in mice was inhibited after AdNT4-anginex treatment for 4 weeks, and a significant decrease in tumor size was observed as compared with the control group. Overall, these studies indicate that AdNT4-anginex is an effective anti-tumor agent, and deserves more attention and research. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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