期刊
CANCER LETTERS
卷 279, 期 2, 页码 155-162出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.01.033
关键词
Berberine; Migration and invasion; Urokinase-type plasminogen activator; Matrix metalloproteinases; SCC-4 cancer cells
类别
资金
- China Medical University, Taiwan [CMU97-094]
- NIH [AG-23524, AG-18357]
There is increasing evidence that urokinase-type plasminogen activator (u-PA) and matrix metalloproteinases (MMPs) play an important role in cancer metastasis and angiogenesis. Inhibition of u-PA and MMPs could suppress migration and invasion of cancer cells. Berberine, one of the main constituents of the plant Rhizoma coptidis, is a type of isoquinoline alkaloid, reported to have anti-cancer effects in different human cancer cell lines. There is however, no available information on effects of berberine on migration and invasion of human tongue cancer cells. Here, we report that berberine inhibited migration and invasion of human SCC-4 tongue squamous carcinoma cells. This action was mediated by the p-JNK, p-ERK, p-p38, I kappa K and NF-kappa B signaling pathways resulting in inhibition of MMP-2 and -9 in human SCC-4 tongue squamous carcinoma cells. Our Western blowing analysis also showed that berberine inhibited the levels of urokinase-plasminogen activator (u-PA). These results suggest that berberine down-regulates u-PA, MMP-2 and -9 expressions in SCC-4 cells through the FAK, IKK and NF-kappa B mediated pathways and a novel function of berberine is to inhibit the invasive capacity of malignant cells. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据