期刊
CANCER LETTERS
卷 278, 期 2, 页码 220-229出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2009.01.007
关键词
Inhibitors of differentiation and DNA binding-1; Androgen deprivation; Androgen deprivation therapy; Androgen independent prostate cancer; Androgen receptor
类别
资金
- Shanghai Health Bureau Youth Fund [2008Y067]
This study discovered that Id-1 expression in androgen-dependent prostate cancer decreased immediately after androgen deprivation but increased after longer androgen deprivation both in vivo and in vitro. Id-1 expression in androgen-independent LNCaP cells was about 6 fold as that in their parental cells. As was the case with LNCaP cells, when androgen receptor (AR) was introduced into AR-negative PC-3 cells, dihydrotestosterone inhibited while flutamide increased Id-1 expression. Thus, Id-1 expression in androgen-dependent prostate cancer was negatively regulated by androgen in a receptor-dependent way. The re-increased Id-1 might partially contribute to the emergence of androgen-independent prostate cancer after longer androgen deprivation therapy. (C) 2009 Elsevier Ireland Ltd. All rights reserved.
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