期刊
CLINICAL OBSTETRICS AND GYNECOLOGY
卷 50, 期 3, 页码 652-683出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/GRF.0b013e31811ebef6
关键词
preterm labor; premature birth; prematurity; funisitis; chorioammionitis; intrauterine infection; PROM
资金
- Intramural NIH HHS Funding Source: Medline
The fetal inflammatory response syndrome (FIRS) is a condition characterized by systemic inflammation and an elevation of fetal plasma interleukin-6. This syndrome has been observed in fetuses with preterm labor with intact membranes, preterm prelabor rupture of the membranes, and also fetal viral infections such as cytomegalovirus. FIRS is a risk factor for short-term perinatal morbidity and mortality after adjustment for gestational age at delivery and also for the development of long-term sequelae such as bronchopulmonary dysplasia and brain injury. Multiorgan involvement in FIRS has been demonstrated in the hematopoietic system, thymus, adrenal glands, skin, kidneys, heart, lung, and brain. This article reviews the fetal systemic inflammatory response as a mechanism of disease. Potential interventions to control an exaggerated inflammatory response in utero are also described.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据