期刊
TRENDS IN NEUROSCIENCES
卷 30, 期 9, 页码 440-446出版社
ELSEVIER SCIENCE LONDON
DOI: 10.1016/j.tins.2007.07.001
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资金
- Intramural NIH HHS Funding Source: Medline
- NATIONAL INSTITUTE ON DRUG ABUSE [Z01DA000493, ZIADA000493] Funding Source: NIH RePORTER
The existence of neurotransmitter receptor heteromers is becoming broadly accepted and their functional significance is being revealed. Heteromerization of neurotransmitter receptors produces functional entities that possess different biochemical characteristics with respect to the individual components of the heteromer. Neurotransmitter receptor heteromers can function as processors of computations that modulate cell signaling. Thus, the quantitative or qualitative aspects of the signaling generated by stimulation of any of the individual receptor units in the heteromer are different from those obtained during coactivation. Furthermore, recent studies demonstrate that some neurotransmitter receptor heteromers can exert an effect as processors of computations that directly modulate both pre- and postsynaptic neurotransmission. This is illustrated by the analysis of striatal receptor heteromers that control striatal glutarnatergic neurotransmission.
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