期刊
CANCER LETTERS
卷 277, 期 2, 页码 205-211出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.12.016
关键词
Fusion gene; Karyotyping; RYK; ATP50; aCML
类别
资金
- Norwegian Cancer Society,
- Swedish Research Council
The analysis of a small number of patients with atypical chronic myeloid leukemia showing balanced chromosomal translocations has revealed diverse tyrosine kinase fusion genes, most commonly involving FGFR1, PDGFRA, PDGFRB, JAK2, and ABL. We present a case of aCML with a 3q22;21q22-translocation that led to truncation of the receptor-like tyrosine kinase (RYK) gene and its juxtaposition with sequences from chromosome 21 including the ATP50 gene coding for a mitochondrial ATP synthase. The resulting fusion was not in frame, however, which is why we speculate that an abrogated RYK gene product rather than a chimeric protein might be the leukemogenic result. (c) 2009 Elsevier Ireland Ltd. All rights reserved.
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