期刊
CANCER LETTERS
卷 278, 期 1, 页码 82-87出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.12.034
关键词
Synergy; 5-aza-2'-deoxycytidine; Paclitaxel; Prostate carcinoma
类别
资金
- Scientific Research Foundation for the Returned Overseas Chinese Scholars, State Education Ministry
To determine the synergy of 5-aza-2'-deoxycytidine (DAC) and paclitaxel (M) against prostate carcinoma (PC) cells by isobolographic analysis. We demonstrated that DAC could significantly increase the susceptibility of PC cells to M, and confirmed the synergy of DAC and PTX DAC enhanced the PTX induced up-regulation of caspase activity and anti-proliferative effect, resulting in an increase of cells in subG1 and G2/M phases. In addition, the synergy was observed in both androgen-dependent and -independent PC cell lines. It suggested that combination chemotherapy with DAC and PTX might be a new strategy to improve the clinical response rate of PC. Crown Copyright (c) 2009 Published by Elsevier Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据