期刊
CANCER LETTERS
卷 269, 期 1, 页码 57-66出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.04.026
关键词
nanotechnology; photothermal therapy; nanorod; hyperthermia; near-infrared; polyethylene glycol
类别
资金
- Georgia Cancer Coalition
- National Cancer Institute [U54CA119338]
- Robinson Family Foundation
- Ovarian Cycle
- US Department of Energy [DE-FG02-97 ER14799]
Plasmonic photothermal therapy (PPTT) is a minimally-invasive oncological treatment strategy in which photon energy is selectively administered and converted into heat sufficient to induce cellular hyperthermia. The present work demonstrates the feasibility of in vivo PPTT treatment of deep-tissue malignancies using easily-prepared plasmonic gold nanorods and a small, portable, inexpensive near-infrared (NIR) laser. Dramatic size decreases in squamous cell carcinoma xenografts were observed for direct (P < 0.0001) and intravenous (P < 0.0008) administration of pegylated gold nanorods in nu/nu mice. Inhibition of average tumor growth for both delivery methods was observed over a 13-day period, with resorption of >57% of the directly-injected tumors and 25% of the intravenously-treated tumors. Published by Elsevier Ltd.
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