期刊
CANCER LETTERS
卷 267, 期 2, 页码 204-215出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.03.028
关键词
tumor-associated macrophages; macrophage polarization; tumour promotion; therapeutic targets; inflammation; cancer; chemokines; cytokines; angiogenesis
类别
资金
- Associazione Italiana Ricerea sul Cancro (AIRC), Italy
- European Community
- Ministero Istruzione Universita Ricerca (MIUR), Italy
- Istituto Superiore Sanita' (ISS)
Tumor-associated macrophages (TAM) are key regulators of the link between inflammation and cancer. In the tumor microenvironment neoplastic cells shape the differentiation and functional orientation of TAM which, in turn, express several protumoral functions, including secretion of growth factors and matrix-proteases. promotion of angiogenesis and suppression of adaptive immunity. This review analyzes our current knowledge of TAM and their involvement in tumor development and progression. The interplay between TAM and neoplastic cells represents a promising target of future therapeutic approaches. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据