期刊
CANCER LETTERS
卷 271, 期 1, 页码 1-12出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.04.036
关键词
Fbxw7; Ubiquitin ligase; Tumor suppressor; Cyclin E1; c-Myc
类别
资金
- American Cancer Society
- Swedish Research Council
- Swedish Cancer Society
- Swedish Children Foundation
Fbxw7/hCdc4 is a member of the F-box family of proteins, which function as interchangeable substrate recognition components of the SCF ubiquitin ligases. SCFFbxw7/hCdc4 targets several important oncoproteins including c-Myc, c-Jun, cyclin El, and Notch, for ubiquitin-dependent proteolysis. Recent studies have shown that FBXW7/hCDC4 is mutated in a variety of human tumor types, suggesting that it is a general tumor suppressor in human cancer. Alteration of Fbxw7/hCdc4 function is linked to defects in differentiation, cellular proliferation, and genetic instability. In this review, we summarize what is known about Fbxw7/hCdc4-mediated degradation in the regulation of cellular proliferation and discuss how alteration of its function contributes to human tumorigenesis. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据