期刊
CANCER LETTERS
卷 267, 期 2, 页码 216-225出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.03.012
关键词
MDSC; inflammation; cancer; NO; immune suppression; arginine metabolism; myeloid cells
类别
资金
- Italian Ministry of Health
- Italian Foundation for Multiple Sclerosis (FISM)
- Italian Association for Cancer Research (AIRC)
- Associazione 'II Faro per lo IOV
- Istituto Superiore Sanita
- Alleanza Contro il Cancro [ACC8]
Chronic inflammatory state can create I proper environment for neoplastic onset and sustain cancer growth. The inflammatory state that arises at the tumor edge could contribute to immune escape phenomena in many ways. Myeloid-derived suppressor cells (MDSCs), a cell population that contributes to tumor escape, immune tolerance, and suppression. respond to a variety of pro-inflammatory and anti-inflammatory stimuli, which drive their recruitment and activation. Understanding how the inflammatory milieu favours tumor escape through the accumulation of MDSCs could be very Useful to improve the efficacy of cancer immunotherapy (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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