期刊
DEVELOPMENT GENES AND EVOLUTION
卷 217, 期 6, 页码 413-420出版社
SPRINGER
DOI: 10.1007/s00427-007-0154-3
关键词
Hox; regeneration; morpholino; electroporation; zebrafish
资金
- NATIONAL INSTITUTE OF ARTHRITIS AND MUSCULOSKELETAL AND SKIN DISEASES [R01AR047233, R01AR039189] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R21DK061373] Funding Source: NIH RePORTER
- NIAMS NIH HHS [AR39189, AR47233] Funding Source: Medline
- NIDDK NIH HHS [R21 DK061373, R21 DK061373-02, DK61373] Funding Source: Medline
Hox genes are re-expressed during regeneration in many species. Given their important role in body plan development, it has been assumed, but not directly shown, that they play a functional role in regeneration. In this paper we show that morpholino-mediated knockdown of either Hoxc13a or Hoxc13b during the process of zebrafish tail fin regeneration results in a significant reduction of regenerative outgrowth. Furthermore, cellular proliferation within the blastema is directly affected in both knockdowns. Hence, similar to the demonstration of unique functions of multiple Hox genes during limb formation, both Hoxc13 orthologs have distinct functions in regeneration.
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