期刊
CANCER LETTERS
卷 272, 期 2, 页码 316-324出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.07.023
关键词
Gene therapy; Head and neck squamous cell carcinoma; Xenograft nude mouse model; IL-2; Adoptive T cell transfer
类别
资金
- Department of Biotechnology, India [BT/PR/5491/Med/14/640/ 2004]
- Advanced Centre for Treatment, Research & Education in Cancer, Mumbai
The potential of cytokine gene therapy using naked plasmid DNA encoding human IL-2 cDNA in a xenograft nude mouse model was investigated. To overcome the T cell deficiency in nude mice, Adoptive T Cell Transfer [ATCT] into tumour bearing nude mice was performed. The migration of T cells was tracked in vivo using USE labeling. IL-2 in circulation was observed till day 15 with the levels reaching a peak by day 3. Significant activation of transferred T cells (CD69(+), CD25(+)) as well as significant increase in levels of NK cells (CD49b(+)) was seen in animals receiving IL-2. Tumour regression was observed in the IL-2+ ATCT group. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
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