期刊
CANCER LETTERS
卷 268, 期 2, 页码 272-277出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.04.001
关键词
hTERT; estradiol; cadmium; melatonin; MCF-7 cells
类别
资金
- Health Institute Carlos III [PI042603]
- MCYT, Spain [SAF2007-62762]
The goal was to evaluate whether melatonin (Mel) down-regulates hTERT expression induced by 17 beta-estradiol (E-2) or cadmium (Cd) in breast cancer cells. We found that: (a) Mel inhibits E-2 or Cd-induced hTERT transcription in hTERT-Luc transfected MCF-7 cells, (b) Mel significantly reduces E-2- and Cd-mediated hTERT transactivation triggered by ER alpha in transfected HeLa cells, (c) Mel inhibits hTERT expression induced by E-2 or Cd in MCF-7 cells. Melatonin inhibition of telomerase activity supports a possible role in treatment of estrogen-dependent tumors or carcinogenesis by environmental or occupational exposure to xenoestrogens. (c) 2008 Elsevier Ireland Ltd. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据