期刊
CURRENT OPINION IN CHEMICAL BIOLOGY
卷 11, 期 2, 页码 121-127出版社
CURRENT BIOLOGY LTD
DOI: 10.1016/j.cbpa.2007.02.039
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资金
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [R01DK068096] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM067169, P20GM072021] Funding Source: NIH RePORTER
- NIDDK NIH HHS [R01 DK068096, DK68096] Funding Source: Medline
- NIGMS NIH HHS [GM072021, GM067169, R01 GM067169] Funding Source: Medline
Synchrotron X-ray fluorescence microscopy (SXRF) is a microanalytical technique for the quantitative mapping of elemental distributions. Among currently available imaging modalities, SXRF is the only technique that is compatible with fully hydrated biological samples such as whole cells or tissue sections, while simultaneously offering trace element sensitivity and submicron spatial resolution. Combined with the ability to provide information regarding the oxidation state and coordination environment of metal cations, SXRF is ideally suited to study the intracellular distribution and speciation of trace elements, toxic heavy metals and therapeutic or diagnostic metal complexes.
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