期刊
CANCER LETTERS
卷 262, 期 1, 页码 1-9出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.01.005
关键词
aurora kinase; cancer; leukemia; mitosis
类别
The Aurora family of serine/threonine kinases plays an important role in chromosome alignment, segregation and cytokinesis during mitosis. Recent studies have found aberrant expression of Aurora kinases in a variety of human solid tumors and hematological malignancies, suggesting they have a role in carcinogenesis. This review highlights the function of Aurora kinases in the regulation of mitosis and presents the rationale for these kinases as an anti-cancer target. I also review recently developed inhibitors of Aurora kinases. (C) 2008 Elsevier Ireland Ltd. All rights reserved.
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