期刊
SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY
卷 18, 期 2, 页码 209-215出版社
ACADEMIC PRESS LTD- ELSEVIER SCIENCE LTD
DOI: 10.1016/j.semcdb.2007.01.003
关键词
mRNA; RNA-binding proteins; microRNAs; posuranscriptional regulation; axons
资金
- NIMH NIH HHS [R01 MH080420, R01 MH080420-01] Funding Source: Medline
- NINDS NIH HHS [R01 NS056306-01A1, R01 NS056306] Funding Source: Medline
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH080420] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE [R01NS056306] Funding Source: NIH RePORTER
The capacity to synthesize proteins in axons is limited to early stages of neuronal development, while axons are undergoing elongation and pathfinding. Although the roles of local protein synthesis are not fully understood, it has been implicated in regulating the morphological plasticity of growth cones. Recent studies have identified specific mRNAs that are translated in growth cones in response to specific extracellular signals. In this review, we discuss the functional relevance of axonal protein translation for developing axons, the differences in translational capacity between developing and mature vertebrate axons, and possible pathways governing the specific translational activation of axonal rnRNAs. (C) 2007 Published by Elsevier Ltd.
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