期刊
CANCER LETTERS
卷 269, 期 1, 页码 67-77出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.canlet.2008.04.032
关键词
breast cancer; mesenchymal stem cell; Wnt signalling pathway; dickkopf-1 (Dkk-1)
类别
资金
- National Basic Research Program of China [2007CB914800]
- National Natural Science Foundation of China [30570698]
We determined the molecular mechanism of inhibitory effect of human mesenchymal stem cells (hMSCs) on the growth of human MCF-7 breast cancer cells. Our finding showed that beta-catenin was down-regulated in MCF-7 cells by conditioned media from D hMSCs, and the expression level of dickkopf-1 (Dkk-1) was higher in Z3 cells than that in MCF-7 cells. Neutralization of Dkk-1 and small interference RNA targeting Dkk-1 mRNA in Z3 cells attenuated the inhibitory effect of D cells on MCF-7 cells. Overexpression of Dkk-1 in Z3 cells enhanced the inhibition. Therefore, Dkk-1 secreted by Z3 cells involves the inhibition via the Writ pathway. Crown copyright (C) 2008 Published by Elsevier Ltd. All rights reserved.
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