期刊
CLIMACTERIC
卷 10, 期 2, 页码 112-119出版社
TAYLOR & FRANCIS LTD
DOI: 10.1080/13697130701258838
关键词
menopausal transition; menopause; menstrual cycle; aging; ovarian function; follicle stimulating hormone
资金
- NATIONAL INSTITUTE OF NURSING RESEARCH [P30NR004001, U01NR004061, R01NR004141] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE ON AGING [U01AG012553, U01AG012546, U01AG012539, U01AG012531, R01AG021543, U01AG012505, U01AG012495, U01AG012554] Funding Source: NIH RePORTER
- NIA NIH HHS [AG012539, AG012531, AG012505, AG012495, AG012546, AG 021543, AG012553, AG012554] Funding Source: Medline
- NINR NIH HHS [NR04001, NR004141, NR004061] Funding Source: Medline
- PHS HHS [EG012535] Funding Source: Medline
In 2001, the Stages of Reproductive Aging Workshop (STRAW) proposed bleeding and endocrine criteria for defining the early and late menopausal transition stages. Based on expert consensus, STRAW recommended a shorter interval of amenorrhea than the commonly used 90-day amenorrhea criteria for late transition and a > 7-day change in cycle length for early transition. The ReSTAGE collaboration used prospective menstrual calendar data from four cohorts (TREMIN, Melbourne Women's Midlife Health Project, Seattle Midlife Women's Health Study, and Study of Women's Health Across the Nation) to quantitatively evaluate STRAW's recommendations. This empirical assessment supported the STRAW recommendations that (1) >= 60 days of amenorrhea be used to define the late menopausal transition and (2) that early transition is consistent with a persistent 7 or more day difference in length of consecutive cycles. Serum follicle stimulating hormone (FSH) values >= 40 IU/I was an independent marker of the transition and, when occurring together with a bleeding marker, increased prediction of final menstrual period. Such a FSH criterion could be incorporated into the STRAW paradigm to facilitate prediction of proximity of the final menstrual period.
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